MaghrebDataLibMedV1, Main, Exploration, bibRecord, 000023

Potential allergenicity of Medicago sativa investigated by a combined IgE-binding inhibition, proteomics and in silico approach.

Identifieur interne : 000023 ( Main/Exploration ); précédent : 000022; suivant : 000024

Potential allergenicity of Medicago sativa investigated by a combined IgE-binding inhibition, proteomics and in silico approach.

Auteurs : Marwa Yakhlef [Algérie, Italie] ; Ivana Giangrieco [Italie] ; Maria A. Ciardiello [Italie] ; Immacolata Fiume [Italie] ; Adriano Mari [Italie] ; Lynda Souiki [Algérie] ; Gabriella Pocsfalvi [Italie]

Source :

Journal of the science of food and agriculture [ 1097-0010 ] ; 2021.

RBID : pubmed:32790067

Descripteurs français

KwdFr :
- Allergènes (composition chimique), Allergènes (génétique), Allergènes (immunologie), Feuilles de plante (composition chimique), Feuilles de plante (génétique), Feuilles de plante (immunologie), Immunoglobuline E (immunologie), Medicago sativa (composition chimique), Medicago sativa (génétique), Medicago sativa (immunologie), Protéines végétales (composition chimique), Protéines végétales (génétique), Protéines végétales (immunologie), Protéomique (MeSH), Réactions croisées (MeSH), Simulation numérique (MeSH), Séquence d'acides aminés (MeSH).
MESH :
- composition chimique : Allergènes, Feuilles de plante, Medicago sativa, Protéines végétales.
- génétique : Allergènes, Feuilles de plante, Medicago sativa, Protéines végétales.
- immunologie : Allergènes, Feuilles de plante, Immunoglobuline E, Medicago sativa, Protéines végétales.
- Protéomique, Réactions croisées, Simulation numérique, Séquence d'acides aminés.

English descriptors

KwdEn :
- Allergens (chemistry), Allergens (genetics), Allergens (immunology), Amino Acid Sequence (MeSH), Computer Simulation (MeSH), Cross Reactions (MeSH), Immunoglobulin E (immunology), Medicago sativa (chemistry), Medicago sativa (genetics), Medicago sativa (immunology), Plant Leaves (chemistry), Plant Leaves (genetics), Plant Leaves (immunology), Plant Proteins (chemistry), Plant Proteins (genetics), Plant Proteins (immunology), Proteomics (MeSH).
MESH :
- chemical , chemistry : Allergens, Plant Proteins.
- chemical , genetics : Allergens, Plant Proteins.
- chemical , immunology : Allergens, Immunoglobulin E, Plant Proteins.
- chemistry : Medicago sativa, Plant Leaves.
- genetics : Medicago sativa, Plant Leaves.
- immunology : Medicago sativa, Plant Leaves.
- Amino Acid Sequence, Computer Simulation, Cross Reactions, Proteomics.

Abstract

BACKGROUND

Alfalfa (Medicago sativa L) is one of the most planted crops worldwide primarily used to feed animals. The use of alfalfa in human diet as sprouts, infusions and nutritional supplements is rapidly gaining popularity. Despite this, allergenicity assessment of this novel plant food is largely lacking.

RESULTS

Here, leaf protein extract of alfalfa was studied using a combined proteomics, Immunoglobulin E (IgE)-binding inhibition assay and in silico approach to find potential allergens. We have identified and annotated 129 proteins using in-gel digestion proteomics and Blast2Go suit. A search against COMPARE database, using the identified proteins as query sequences, revealed high similarity with several allergenic proteins. The Single Point Highest Inhibition Achievable assay (SPHIAa) performed on the multiplex FABER

CONCLUSION

This study reports for the first time potential allergenic proteins in alfalfa. The results suggest that this plant food can be safely introduced, as a protein-rich supplement, in the diet of patients allergic to animal food allergens. Allergic patients towards certain plant food allergens need to be careful about consuming alfalfa because they might have allergic symptoms. © 2020 Society of Chemical Industry.

DOI: 10.1002/jsfa.10730
PubMed: 32790067

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Allergens (genetics)</term>
<term>Allergens (immunology)</term>
<term>Amino Acid Sequence (MeSH)</term>
<term>Computer Simulation (MeSH)</term>
<term>Cross Reactions (MeSH)</term>
<term>Immunoglobulin E (immunology)</term>
<term>Medicago sativa (chemistry)</term>
<term>Medicago sativa (genetics)</term>
<term>Medicago sativa (immunology)</term>
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<term>Plant Leaves (genetics)</term>
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<term>Plant Proteins (genetics)</term>
<term>Plant Proteins (immunology)</term>
<term>Proteomics (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Allergènes (composition chimique)</term>
<term>Allergènes (génétique)</term>
<term>Allergènes (immunologie)</term>
<term>Feuilles de plante (composition chimique)</term>
<term>Feuilles de plante (génétique)</term>
<term>Feuilles de plante (immunologie)</term>
<term>Immunoglobuline E (immunologie)</term>
<term>Medicago sativa (composition chimique)</term>
<term>Medicago sativa (génétique)</term>
<term>Medicago sativa (immunologie)</term>
<term>Protéines végétales (composition chimique)</term>
<term>Protéines végétales (génétique)</term>
<term>Protéines végétales (immunologie)</term>
<term>Protéomique (MeSH)</term>
<term>Réactions croisées (MeSH)</term>
<term>Simulation numérique (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Allergens</term>
<term>Plant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Allergens</term>
<term>Plant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Allergens</term>
<term>Immunoglobulin E</term>
<term>Plant Proteins</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Medicago sativa</term>
<term>Plant Leaves</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Allergènes</term>
<term>Feuilles de plante</term>
<term>Medicago sativa</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Medicago sativa</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Allergènes</term>
<term>Feuilles de plante</term>
<term>Medicago sativa</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Allergènes</term>
<term>Feuilles de plante</term>
<term>Immunoglobuline E</term>
<term>Medicago sativa</term>
<term>Protéines végétales</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Medicago sativa</term>
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<term>Cross Reactions</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Alfalfa (Medicago sativa L) is one of the most planted crops worldwide primarily used to feed animals. The use of alfalfa in human diet as sprouts, infusions and nutritional supplements is rapidly gaining popularity. Despite this, allergenicity assessment of this novel plant food is largely lacking.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Here, leaf protein extract of alfalfa was studied using a combined proteomics, Immunoglobulin E (IgE)-binding inhibition assay and in silico approach to find potential allergens. We have identified and annotated 129 proteins using in-gel digestion proteomics and Blast2Go suit. A search against COMPARE database, using the identified proteins as query sequences, revealed high similarity with several allergenic proteins. The Single Point Highest Inhibition Achievable assay (SPHIAa) performed on the multiplex FABER</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>This study reports for the first time potential allergenic proteins in alfalfa. The results suggest that this plant food can be safely introduced, as a protein-rich supplement, in the diet of patients allergic to animal food allergens. Allergic patients towards certain plant food allergens need to be careful about consuming alfalfa because they might have allergic symptoms. © 2020 Society of Chemical Industry.</p>
</div>
</front>
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<DateCompleted><Year>2021</Year>
<Month>03</Month>
<Day>29</Day>
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<Month>03</Month>
<Day>29</Day>
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<Issue>3</Issue>
<PubDate><Year>2021</Year>
<Month>Feb</Month>
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<Title>Journal of the science of food and agriculture</Title>
<ISOAbbreviation>J Sci Food Agric</ISOAbbreviation>
</Journal>
<ArticleTitle>Potential allergenicity of Medicago sativa investigated by a combined IgE-binding inhibition, proteomics and in silico approach.</ArticleTitle>
<Pagination><MedlinePgn>1182-1192</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/jsfa.10730</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Alfalfa (Medicago sativa L) is one of the most planted crops worldwide primarily used to feed animals. The use of alfalfa in human diet as sprouts, infusions and nutritional supplements is rapidly gaining popularity. Despite this, allergenicity assessment of this novel plant food is largely lacking.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Here, leaf protein extract of alfalfa was studied using a combined proteomics, Immunoglobulin E (IgE)-binding inhibition assay and in silico approach to find potential allergens. We have identified and annotated 129 proteins using in-gel digestion proteomics and Blast2Go suit. A search against COMPARE database, using the identified proteins as query sequences, revealed high similarity with several allergenic proteins. The Single Point Highest Inhibition Achievable assay (SPHIAa) performed on the multiplex FABER<sup>®</sup>
 allergy testing system confirmed the in silico results and showed some additional potential allergens. This approach allowed the detection of proteins in alfalfa leaves cross-reacting with plant allergens from three different allergen families such as lipid transfer, thaumatin-like and Bet v 1-like protein families. In addition, the absence of structural determinants cross-reacting with seed storage allergenic proteins and with animal allergens was recorded.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This study reports for the first time potential allergenic proteins in alfalfa. The results suggest that this plant food can be safely introduced, as a protein-rich supplement, in the diet of patients allergic to animal food allergens. Allergic patients towards certain plant food allergens need to be careful about consuming alfalfa because they might have allergic symptoms. © 2020 Society of Chemical Industry.</AbstractText>
<CopyrightInformation>© 2020 Society of Chemical Industry.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yakhlef</LastName>
<ForeName>Marwa</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Biologie, Eau et Environnement, Department of Biology, Faculté des Sciences de la Nature et de la Vie et Sciences de la Terre et l'Univers, Université 8 Mai 1945 Guelma, Guelma, Algeria.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Biosciences and BioResources, National Research Council, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Giangrieco</LastName>
<ForeName>Ivana</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Institute of Biosciences and BioResources, National Research Council, Naples, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Allergy Data Laboratories (ADL), Latina, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ciardiello</LastName>
<ForeName>Maria A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Institute of Biosciences and BioResources, National Research Council, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fiume</LastName>
<ForeName>Immacolata</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Institute of Biosciences and BioResources, National Research Council, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mari</LastName>
<ForeName>Adriano</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Allergy Data Laboratories (ADL), Latina, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Associated Centre for Molecular Allergology, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Souiki</LastName>
<ForeName>Lynda</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Faculté des Sciences de la Nature et de la Vie et Sciences de la Terre et l'Univers, Université 8 Mai 1945 Guelma, Guelma, Algeria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pocsfalvi</LastName>
<ForeName>Gabriella</ForeName>
<Initials>G</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-6065-3853</Identifier>
<AffiliationInfo><Affiliation>Institute of Biosciences and BioResources, National Research Council, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
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Potential allergenicity of Medicago sativa investigated by a combined IgE-binding inhibition, proteomics and in silico approach.

Potential allergenicity of Medicago sativa investigated by a combined IgE-binding inhibition, proteomics and in silico approach.

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